<p>Myelodysplastic Syndromes (MDS) are heterogeneous myeloid neoplasms, characterized by stepwise acquisitions of multiple somatic mutations. Mutational configurations (e.g. bi-allelic) and specific distributions, timing of acquisitions corresponding to rank within the clonal hierarchy, and combinatorial spectrum are not elucidated. Therefore, we conducted targeted deep sequencing in a panel of the 36 most frequently mutated "myeloid" genes in terms more than of 500 patients with MDS or related myeloid neoplasms.</p>

Invariant Patterns of Clonal Succession Determine Specific Clinical    Features of Myelodysplastic Syndromes (MDS)

1 selected publication including "Invariant patterns of clonal succession determine specific clinical fe..." (54 citations)

Invariant Patterns of Clonal Succession Determine Specific Clinical Features of Myelodysplastic Syndromes (MDS)

Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes