<p>While splicing changes caused by somatic mutations in SF3B1 are known, identifying full-length isoform changes may better elucidate the functional consequences of these mutations. We have performed nanopore sequencing of full-length cDNA from CLL samples with and without SF3B1 mutation, as well as normal B cell samples. With long reads, we analyzed alternative splicing patterns associated with SF3B1 mutation at an isoform-level.</p>

Nanopore Sequencing of Chronic Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic, B-Cell study with RNA-Seq, SRA Metadata data on dbGaP (9 participants)