<p>Rhabdomyosacoma (RMS) is a common pediatric soft tissue tumor that is associated with the skeletal muscle lineage. RMS comprises two major subtypes: fusion-positive (FP, most commonly <a href="https://www.ncbi.nlm.nih.gov/gene/?term=5077">PAX3</a>- <a href="https://www.ncbi.nlm.nih.gov/gene/?term=2308">FOXO1</a> or <a href="https://www.ncbi.nlm.nih.gov/gene/?term=5081">PAX7</a>-FOXO1) and fusion-negative (FN, frequently associated with mutations in RAS pathway). Our previous study demonstrated that FP and FN tumors exhibit distinct DNA methylation profiles. In this study, further investigation of genome-wide DNA methylation profiles in RMS tumors revealed DNA methylation differences between AX3-FOXO1 and PAX7-FOXO1 subsets in FP RMS, and between RAS mutation and RAS wild-type subsets in FN RMS. These data provide new insight into the relationship of DNA methylation with mutational changes and transcriptional organization in FP and FN RMS.</p>

DNA Methylation in Rhabdomyosarcoma

1 selected publication including "Relationship of DNA methylation to mutational changes and transcriptio..." (18 citations)

DNA Methylation in Rhabdomyosarcoma

Relationship of DNA methylation to mutational changes and transcriptional organization in fusion‐positive and fusion‐negative rhabdomyosarcoma