<p>This study is designed to understand the role of immunosuppressive regulatory B cells (Breg) in pancreatic cancer. Breg and conventional B cells (Bcon) from patients are compared by RNA sequencing analysis. Bregs and Bcon were isolated from freshly isolated PBMCs in peripheral blood. These data represent the examination of differentially expressed genes in these two blood-derived B cell subsets from both healthy and pancreatic cancer patients.</p>

Advanced Genetic and Molecular Analysis of Solid Tumors

2 selected publications including "B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pa..." (85 citations)

Advanced Genetic and Molecular Analysis of Solid Tumors

B cell–Derived IL35 Drives STAT3-Dependent CD8+ T-cell Exclusion in Pancreatic Cancer

IL35 Hinders Endogenous Antitumor T-cell Immunity and Responsiveness to Immunotherapy in Pancreatic Cancer