<p>Germ cell tumors (GCTs) are cancers of the testis, ovary and extragonadal sites that occur in infants, children, adolescents, and adults. Post-pubertal (type II) malignant GCTs may present as a seminoma, non-seminoma or with mixed histologies. In contrast, pre-pubertal (type I) GCTs are limited to (benign) teratomas and (malignant) yolk sac tumors (YST). Epidemiologic and molecular data have shown that pre- and post-pubertal GCTs arise by distinct mechanisms. Dedicated studies of the genomic landscape of type I and II GCTs in children and adolescents are lacking. Here we present an integrated genomic analysis of extracranial GCTs across the age spectrum from 0-24 years.</p>

Genomic Landscape of Pediatric Germ Cell Tumors

2 selected publications including "GCNA preserves genome integrity and fertility across species" (57 citations)

Genomic Landscape of Pediatric Germ Cell Tumors

GCNA preserves genome integrity and fertility across species

Identification of testicular cancer driver genes by a cross‐species comparative oncology approach