National Eye Institute (NEI) Age-Related Eye Disease Study 2 (AREDS2)

Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.

E. Chew, T. Clemons, J. Sangiovanni, et al.. (2013). JAMA. Cited 1,182 times. https://doi.org/10.1001/jama.2013.4997

Secondary analyses of the effects of lutein/zeaxanthin on age-related macular degeneration progression: AREDS2 report No. 3.

E. Chew, T. Clemons, J. Sangiovanni, et al.. (2014). JAMA ophthalmology. Cited 402 times. https://doi.org/10.1001/jamaophthalmol.2013.7376

The Age-Related Eye Disease Study 2 (AREDS2): study design and baseline characteristics (AREDS2 report number 1).

E. Chew, T. Clemons, J. Sangiovanni, et al.. (2012). Ophthalmology. Cited 384 times. https://doi.org/10.1016/j.ophtha.2012.05.027

Imaging Protocols in Clinical Studies in Advanced Age-Related Macular Degeneration: Recommendations from Classification of Atrophy Consensus Meetings.

F. Holz, S. Sadda, G. Staurenghi, et al.. (2017). Ophthalmology. Cited 209 times. https://doi.org/10.1016/j.ophtha.2016.12.002

Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.

T. Keenan, E. Agrón, A. Domalpally, et al.. (2018). Ophthalmology. Cited 186 times. https://doi.org/10.1016/j.ophtha.2018.05.028

Randomized trial of a home monitoring system for early detection of choroidal neovascularization home monitoring of the Eye (HOME) study.

E. Chew, T. Clemons, S. Bressler, et al.. (2014). Ophthalmology. Cited 185 times. https://doi.org/10.1016/j.ophtha.2013.10.027

Effect of Omega-3 Fatty Acids, Lutein/Zeaxanthin, or Other Nutrient Supplementation on Cognitive Function: The AREDS2 Randomized Clinical Trial.

E. Chew, T. Clemons, E. Agrón, et al.. (2015). JAMA. Cited 165 times. https://doi.org/10.1001/jama.2015.9677

Lutein/zeaxanthin for the treatment of age-related cataract: AREDS2 randomized trial report no. 4.

E. Chew, J. Sangiovanni, F. Ferris, et al.. (2013). JAMA ophthalmology. Cited 141 times. https://doi.org/10.1001/jamaophthalmol.2013.4412

Methods and reproducibility of grading optimized digital color fundus photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2).

R. Danis, A. Domalpally, E. Chew, et al.. (2013). Investigative ophthalmology & visual science. Cited 121 times. https://doi.org/10.1167/iovs.13-11804

Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks

(2018). JAMA Cardiology. Cited 106 times. https://doi.org/10.1001/jamacardio.2017.5205

Drusen Volume and Retinal Pigment Epithelium Abnormal Thinning Volume Predict 2-Year Progression of Age-Related Macular Degeneration.

F. Folgar, Eric L Yuan, Monica B. Sevilla, et al.. (2016). Ophthalmology. Cited 106 times. https://doi.org/10.1016/j.ophtha.2015.09.016

Prevalence, Risk, and Genetic Association of Reticular Pseudodrusen in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 Report 21.

A. Domalpally, E. Agrón, Jeong W. Pak, et al.. (2019). Ophthalmology. Cited 102 times. https://doi.org/10.1016/J.OPHTHA.2019.07.022

Effect of long-chain ω-3 fatty acids and lutein + zeaxanthin supplements on cardiovascular outcomes: results of the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial.

D. Bonds, M. Harrington, B. Worrall, et al.. (2014). JAMA internal medicine. Cited 102 times. https://doi.org/10.1001/jamainternmed.2014.328

Optical Coherence Tomography Predictors of Risk for Progression to Non-Neovascular Atrophic Age-Related Macular Degeneration.

Karim Sleiman, M. Veerappan, K. Winter, et al.. (2017). Ophthalmology. Cited 89 times. https://doi.org/10.1016/j.ophtha.2017.06.032

Peripheral Retinal Changes Associated with Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 12 by the Age-Related Eye Disease Study 2 Optos PEripheral RetinA (OPERA) Study Research Group.

A. Domalpally, T. Clemons, R. Danis, et al.. (2017). Ophthalmology. Cited 85 times. https://doi.org/10.1016/j.ophtha.2016.12.004

Genome-wide analysis of disease progression in age-related macular degeneration

Qi Yan, Ying Ding, Yi Liu, et al.. (2018). Human Molecular Genetics. Cited 82 times. https://doi.org/10.1093/hmg/ddy002

Optical Coherence Tomography Reflective Drusen Substructures Predict Progression to Geographic Atrophy in Age-related Macular Degeneration.

M. Veerappan, Abdul-Karim M. El-Hage-Sleiman, Vincent Tai, et al.. (2016). Ophthalmology. Cited 78 times. https://doi.org/10.1016/j.ophtha.2016.08.047

Retinal specialist versus artificial intelligence detection of retinal fluid from optical coherence tomography: AREDS2 10-year Follow-On.

T. Keenan, T. Clemons, A. Domalpally, et al.. (2020). Ophthalmology. Cited 70 times. https://doi.org/10.1016/j.ophtha.2020.06.038

Adherence to the Mediterranean diet and progression to late age-related macular degeneration in the Age-Related Eye Disease Studies 1 and 2.

T. Keenan, E. Agrón, J. Mares, et al.. (2020). Ophthalmology. Cited 70 times. https://doi.org/10.1016/j.ophtha.2020.04.030

Randomized trial of the ForeseeHome monitoring device for early detection of neovascular age-related macular degeneration. The HOme Monitoring of the Eye (HOME) study design - HOME Study report number 1.

E. Chew, T. Clemons, S. Bressler, et al.. (2014). Contemporary clinical trials. Cited 61 times. https://doi.org/10.1016/j.cct.2014.02.003

Bivariate Analysis of Age-Related Macular Degeneration Progression Using Genetic Risk Scores

Ying Ding, Yi Liu, Qi Yan, et al.. (2017). Genetics. Cited 54 times. https://doi.org/10.1534/genetics.116.196998

A multi-task deep learning model for the classification of Age-related Macular Degeneration

Qingyu Chen, Yifan Peng, T. Keenan, et al.. (2018). AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science. Cited 51 times.

Age-related Eye Disease Study 2: perspectives, recommendations, and unanswered questions

Mary E. Aronow, E. Chew. (2014). Current Opinion in Ophthalmology. Cited 51 times. https://doi.org/10.1097/ICU.0000000000000046

Natural History of Drusenoid Pigment Epithelial Detachment Associated with Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report No. 17.

Jeannette J. Yu, E. Agrón, T. Clemons, et al.. (2019). Ophthalmology. Cited 47 times. https://doi.org/10.1016/j.ophtha.2018.08.017

Visual acuity after cataract surgery in patients with age-related macular degeneration: age-related eye disease study 2 report number 5.

N. Huynh, B. Nicholson, E. Agrón, et al.. (2014). Ophthalmology. Cited 37 times. https://doi.org/10.1016/j.ophtha.2013.12.035

Deep learning automated detection of reticular pseudodrusen from fundus autofluorescence images or color fundus photographs in AREDS2.

T. Keenan, Qingyu Chen, Yifan Peng, et al.. (2020). Ophthalmology. Cited 34 times. https://doi.org/10.1016/j.ophtha.2020.05.036

A Deep Phenotype Association Study Reveals Specific Phenotype Associations with Genetic Variants in Age-related Macular Degeneration: Age-Related Eye Disease Study 2 (AREDS2) Report No. 14.

F. van Asten, M. Simmons, Ayush Singhal, et al.. (2018). Ophthalmology. Cited 34 times. https://doi.org/10.1016/j.ophtha.2017.09.023

Atrophy in Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 15.

Amithia Domalpally, R. Danis, R. Trane, et al.. (2018). Ophthalmology. Retina. Cited 31 times. https://doi.org/10.1016/j.oret.2018.04.009

The Association of Statin Use with Age-Related Macular Degeneration Progression: The Age-Related Eye Disease Study 2 Report Number 9.

Shaza N Al-Holou, W. Tucker, E. Agrón, et al.. (2015). Ophthalmology. Cited 31 times. https://doi.org/10.1016/j.ophtha.2015.08.028

Association of Mortality with Ocular Diseases and Visual Impairment in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report Number 13.

Chandana Papudesu, T. Clemons, E. Agrón, et al.. (2017). Ophthalmology. Cited 30 times. https://doi.org/10.1016/j.ophtha.2017.10.028

Adherence to a Mediterranean diet and cognitive function in the Age‐Related Eye Disease Studies 1 & 2

T. Keenan, E. Agrón, J. Mares, et al.. (2020). Alzheimer's & Dementia. Cited 30 times. https://doi.org/10.1002/alz.12077

Association of 2-Year Progression Along the AREDS AMD Scale and Development of Late Age-Related Macular Degeneration or Loss of Visual Acuity: AREDS Report 22.

S. Vitale, E. Agrón, T. Clemons, et al.. (2020). JAMA ophthalmology. Cited 25 times. https://doi.org/10.1001/jamaophthalmol.2020.0824

Visual Acuity Outcomes after Anti-Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration: Age-Related Eye Disease Study 2 Report Number 19.

T. Keenan, S. Vitale, E. Agrón, et al.. (2019). Ophthalmology. Retina. Cited 24 times. https://doi.org/10.1016/j.oret.2019.06.001

No CFH or ARMS2 Interaction with Omega-3 Fatty Acids, Low versus High Zinc, or β-Carotene versus Lutein and Zeaxanthin on Progression of Age-Related Macular Degeneration in the Age-Related Eye Disease Study 2: Age-Related Eye Disease Study 2 Report No. 18.

F. van Asten, Chi-Yang Chiu, E. Agrón, et al.. (2019). Ophthalmology. Cited 21 times. https://doi.org/10.1016/J.OPHTHA.2019.06.004

The Association of Aspirin Use with Age-Related Macular Degeneration Progression in the Age-Related Eye Disease Studies: Age-Related Eye Disease Study 2 Report No. 20.

T. Keenan, H. Wiley, E. Agrón, et al.. (2019). Ophthalmology. Cited 16 times. https://doi.org/10.1016/J.OPHTHA.2019.06.023

Imaging Characteristics of Choroidal Neovascular Lesions in the AREDS2-HOME Study: Report Number 4.

A. Domalpally, T. Clemons, S. Bressler, et al.. (2019). Ophthalmology. Retina. Cited 16 times. https://doi.org/10.1016/J.ORET.2019.01.004

The Association of Statin Use with Cataract Progression and Cataract Surgery: The AREDS2 Report Number 8.

Shaza N Al-Holou, W. Tucker, E. Agrón, et al.. (2016). Ophthalmology. Cited 15 times. https://doi.org/10.1016/j.ophtha.2015.10.040

Association of Rare Predicted Loss-of-Function Variants in Cellular Pathways with Sub-Phenotypes in Age-Related Macular Degeneration.

Alexandra A. Pietraszkiewicz, F. van Asten, Alan M. Kwong, et al.. (2017). Ophthalmology. Cited 13 times. https://doi.org/10.1016/j.ophtha.2017.10.027

Evaluation of optimized digital fundus reflex photographs for lens opacities in the age-related eye disease study 2: AREDS2 report 7.

A. Domalpally, R. Danis, E. Chew, et al.. (2013). Investigative ophthalmology & visual science. Cited 9 times. https://doi.org/10.1167/iovs.13-12301

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T. Keenan, E. Agrón, E. Chew. (2019). Ophthalmology. Cited 1 times. https://doi.org/10.1016/j.ophtha.2018.11.030