<p>The CS-MATCH-0007 protocol is part of a collaboration between the Center for Cancer Genomics (CCG) and the Division of Cancer Treatment and Diagnosis (DCTD) to perform whole-exome sequencing, RNA sequencing and if possible, whole-genome, methylation and miRNA sequencing using pre-and post-treatment tumor biopsy specimens from patients enrolled on a treatment arm of the <a href="https://clinicaltrials.gov/ct2/show/NCT02465060?term=NCT02465060&#x26;rank=1">NCI-MATCH clinical trial (EAY131)</a>. The goal of this study is to identify the molecular basis for response and resistance to targeted therapies that are matched to specific genomic alterations found in their cancers. Arm B is one of the treatment sub-protocols within the <a href="https://clinicaltrials.gov/ct2/show/NCT02465060?term=NCT02465060&#x26;rank=1">NCI-MATCH Clinical Trial (EAY131)</a> where patients with HER2- activating mutations are treated with Afatinib. This subprotocol is one of the treatment arms included in the CS-MATCH-0007 protocol and will provide specimens for the program including DNA from tumor tissue and whole blood.</p>

Genomic Characterization CS-MATCH-0007 Arm B