Intraductal Transplantation Models of PDAC Reveal Progression of Subtypes

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Demographics (3)

  • AGE - Age at diagnosis (phv00431132.v1.p1)
  • DAY_SAMPLE_HARVESTED - The number of days after initial transplant that the tumor was harvested, or the number of days after plating that the organoids were harvested (phv00431148.v1.p1)
  • SEX - Sex of participant (phv00431131.v1.p1)

Disease Events (1)

  • AFFECTION_STATUS - Case control status of the subject for pancreatic ductal adenocarcinoma (PDAC) (phv00431130.v1.p1)

Race and Ethnicity (1)

Other (21)

  • ANALYTE_TYPE - Analyte type of sample (phv00431138.v1.p1)
  • BODY_SITE - Site in the patient's body where the specimen used to generate the organoid line was collected (phv00431135.v1.p1)
  • CLONE_ID - For samples derived from clonal organoids or xenografts of clonal organoids, the clone ID of the organoid (phv00431303.v1.p1)
  • CONSENT - Consent group as determined by DAC (phv00431126.v1.p1)
  • CONTROL_STATUS - For experiments that compared treated cells or mice to controls (project analyses 4 and 5 detailed below), this describes whether the sample was a case or a control (phv00431137.v1.p1)
  • ENGRAFTMENT_MODEL - Method used to engraft patient-derived organoid cells into the pancreas of NSG (NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ) mice (phv00431142.v1.p1)
  • HISTOLOGICAL_TYPE - Histology of sample (phv00431139.v1.p1)
  • IGO_PROGRESSOR_TYPE - For tumors arising from intraductally grafted organoids (IGOs) that were used to compare fast- vs. slow-progessing IGO tumors (i.e. tumors used to generate samples used for Project Analyses 2 or 3), the relative speed of progression (phv00431144.v1.p1)
  • IS_TUMOR - Tumor status of sample (phv00431140.v1.p1)
  • ISOLATED_REGION - Region isolated by laser-capture microdissection of IGO-derived tumors used for Project Analyses 6, 7, and 8 (phv00431147.v1.p1)
  • KRAS_IN_VITRO - Treatment of the organoids used for comparison of cultured organoids in which oncogenic KRAS was hyperactivated vs untreated, control organoids for Project Analysis 5 (phv00431146.v1.p1)
  • KRAS_IN_VIVO - Vector construct present in the organoids used to generate the IGO tumors used to compare laser-capture microdissected KRAS-hyperactivated or control regions for Project Analysis 4 (phv00431145.v1.p1)
  • ORGANOID_USED - Organoid line used to generate this sample (phv00431302.v1.p1)
  • PROJECT_ANALYSIS - Type of analysis in which the sample was included (phv00431143.v1.p1)
  • SAMPLE_ID - De-identified Sample ID (phv00431134.v1.p1)
  • SAMPLE_ID - Sample ID (phv00431128.v1.p1)
  • SAMPLE_TYPE - Preclinical model system used to generate sample. For samples with SAMPLE_TYPE=ORGANOID, the name of the organoid used to generate the sample. For samples with SAMPLE_TYPE=IGO_LCM or XENOGRAFT, the name of the organoid transplanted to generate the xenograft tumor. (phv00431141.v1.p1)
  • SUBJECT_ID - De-identified Subject ID (phv00431129.v1.p1)
  • SUBJECT_ID - Subject ID (phv00431125.v1.p1)
  • SUBJECT_ID - Subject ID (phv00431127.v1.p1)
  • XENOGRAFT_BODY_SITE - For xenografts of patient-derived organoids, the site in the mouse's body from which the sample was collected (phv00431136.v1.p1)