<p>Colorectal cancer, the second most commonly diagnosed cancer, is a biologically heterogeneous disease. To characterize the molecular attributes of colorectal tumors, we conducted targeted sequencing at the Ontario Cancer Research Institution (OICR) of tumor and matched normal DNA samples from 2,542 colorectal cancer cases in the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO) [<a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001078">phs001078</a>] and the Colon Cancer Family Registry (CCFR). These consortia are based on cohort and population-based case-control studies.</p>

OICR: Molecular Pathological Epidemiology of Colorectal Cancer

Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival