<p>In order to evaluate the effects of TFEB, a master regulator of autophagy and lysosomal biogenesis, CRISPR-Cas9 TFEB knock out cell lines were generated and reconstituted with wild-type TFEB (TFEB-WT), a vector control (TFEB-KO) or TFEB engineered to remain localized to the cytosol (TFEB-cyto) or to the nucleus (TFEB-nuc). RNA sequencing was performed on engineered cell lines at steady-state or following exogenous stimulation with autophagy inducer (Torin1 or Salmonella bacterial infection). Comparative analyses were performed to identify TFEB-dependent transcriptional response to subcellular localization at steady-state or to exogenous stimuli.</p>

Systematic Analysis of Transcription Program Regulation by Transcription    Factor EB (TFEB)

TFEB protein, human study with RNA-Seq data on dbGaP (1 participants)

Systematic Analysis of Transcription Program Regulation by Transcription Factor EB (TFEB)

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