<p>Our study aimed to define the extent of heterogeneity between anatomically separated tumor manifestations in follicular lymphoma at single-cell resolution. We subjected single-cell suspensions derived from nodal, synchronously-acquired fine needle aspirations from two distinct tumor sites to high-throughput microfluidics-based single-cell RNA sequencing. By comparing the relative composition of the tumor subpopulations between the two tumor sites, we found that some patients can exhibit site-to-site differences. While the overall composition of the tumor microenvironment did not differ significantly between sites, we did detect a specific correlation between site-to-site tumor heterogeneity and T follicular helper cell abundance. Our study demonstrates the significant limitations of a solitary biopsy in defining the full scope of a patient's disease.</p>

Single Cell Genomic Analysis of Lymphoma

1 selected publication including "Single Cell Analysis Can Define Distinct Evolution of Tumor Sites in F..." (67 citations)

Single Cell Genomic Analysis of Lymphoma

Single Cell Analysis Can Define Distinct Evolution of Tumor Sites in Follicular Lymphoma.