<p>Mutations in splicing factor genes are common in myelodysplastic syndromes but the reason for selection of these mutations remains incompletely understood. This study aimed to identify the effect of minor intron retention due to ZRSR2 mutations in myelodysplastic syndromes. Nine samples from patients with myelodysplastic syndromes bearing ZRSR2 mutations and ten samples from patients with myelodysplastic syndromes not bearing any splicing factor mutations were subjected to transcriptomic analysis for mis-splicing events after RNA-sequencing. </p>

ZRSR2 Mutant Myelodysplastic Syndromes

Myelodysplastic Syndromes study with RNA-Seq, RNA Seq (NGS) data on dbGaP (18 participants)