<p>We profiled the transcriptomes of individual cells obtained from bone marrow aspirates of 7 treatment-naïve newly diagnosed <i>JAK2</i>-mutant myeloproliferative neoplasm (MPN) patients (3 polycythemia vera and 4 essential thrombocythemia patients), and 2 healthy controls. The submitted data corresponds to sequencing reads mapped to the human reference genome GhRC38 build using CellRanger for a total of 9 samples (one per patient).</p>
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</div><div>In addition, to reconstruct the lineage histories of single cells in MPN patients, we performed whole-genome sequencing of single-cell-derived colonies of hematopoietic stem and progenitor cells from 2 essential thrombocythemia (ET) patients: 22 <i>JAK2</i>-mutant colonies and 20 WT colonies for patient ET 1; and 13 <i>JAK2</i>-mutant colonies and 21 WT colonies for patient ET 2.  The submitted data consists of sequencing reads aligned to the human reference genome GhRC38 build using bwa-mem. Each file corresponds to the whole-genome sequencing data for one colony.
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Characterizing Individual Cells Obtained from Bone Marrow Biopsies of MPN    Patients

Myeloproliferative Disorders study with RNA-Seq, WGS data on dbGaP (9 participants)