<p>We studied the genomic signatures of progression in breast ductal carcinoma in situ (DCIS) as it progresses towards triple negative invasive breast cancer (TNBC). Single cell RNA sequencing (scRNAseq) was performed on the C3Tag genetically engineered mouse model that forms human breast-like DCIS and TNBC. Bulk RNA sequencing was performed on RNA harvested from archival formalin-fixed, paraffin embedded (FFPE) pairs comprising of estrogen receptor (ER) positive (ER+) and negative (ER-) subsets of DCIS. </p>

Molecular Signatures of DCIS to Invasive Progression for Basal-Like    Breast Cancers: An Integrated Mouse Model and Human Tumor Study

16 variables across Demographics, Disease Events

Variables — phs002443 — Molecular Signatures of DCIS to Invasive Progression for Basal-Like    Breast Cancers: An Integrated Mouse Model and Human Tumor Study

Molecular Signatures of DCIS to Invasive Progression for Basal-Like Breast Cancers: An Integrated Mouse Model and Human Tumor Study

Demographics (1)

Disease Events (5)

Other (10)