<p>Current pharmacogenetic approaches often use a few large-effect alleles to predict drug outcomes. However, many drug outcome phenotypes are determined by complex pathways that may be influenced by common single-nucleotide variants (SNVs) across the genome. We ascertained how much variation in drug response is explained by common SNVs for pharmacokinetic (drug levels) and pharmacodynamic phenotypes (highest creatinine) for 4 drugs: vancomycin, gentamicin, cyclosporine and tacrolimus.</p>

Genome-Wide Approach to Measure Variant-Based Heritability of Drug    Outcome Phenotypes

Pharmacology study with SNP/CNV (Array) data on dbGaP (7,093 participants)

Genome-Wide Approach to Measure Variant-Based Heritability of Drug Outcome Phenotypes

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