<p>Current pharmacogenetic approaches often use a few large-effect alleles to predict drug outcomes. However, many drug outcome phenotypes are determined by complex pathways that may be influenced by common single-nucleotide variants (SNVs) across the genome. We ascertained how much variation in drug response is explained by common SNVs for pharmacokinetic (drug levels) and pharmacodynamic phenotypes (highest creatinine) for 4 drugs: vancomycin, gentamicin, cyclosporine and tacrolimus.</p>

Genome-Wide Approach to Measure Variant-Based Heritability of Drug    Outcome Phenotypes

1 selected publication including "Genome‐Wide Approach to Measure Variant‐Based Heritability of Drug Out..." (11 citations)

Genome-Wide Approach to Measure Variant-Based Heritability of Drug Outcome Phenotypes

Genome‐Wide Approach to Measure Variant‐Based Heritability of Drug Outcome Phenotypes