<p>In adult systems vaccinology studies, baseline immune status (i.e. pre-vaccine) of vaccine recipients was highly predictive of vaccine immunogenicity. The aim of this study is to characterize pre-vaccine immune signatures that predict immunogenicity of HBV in humans using single cell transcriptomics. To investigate the pre-vaccine status of these patients, we characterized transcriptomic responses in 5 FACS sorted populations of circulating immune cells, mDCs, monocytes, pDCs, natural killer cells and neutrophils, sample at baseline, 3, 7 and 14 days after vaccination. <br></p>

Human Vaccines Project: scRNAseq Characterization of HepB Vaccine    Response

1 selected publication including "Systems Biology Methods Applied to Blood and Tissue for a Comprehensiv..." (16 citations)

Human Vaccines Project: scRNAseq Characterization of HepB Vaccine Response

Systems Biology Methods Applied to Blood and Tissue for a Comprehensive Analysis of Immune Response to Hepatitis B Vaccine in Adults