<p>Actionable oncogenic alterations are identified in a subset of lung adenocarcinomas.  Many of these driver alterations are enriched in lung adenocarcinomas from individuals with minimal smoking history and are generally mutually exclusive of one another.  We generated whole-exome and RNA-seq data from lung adenocarcinomas obtained from individuals with ≤10 pack-year smoking history.  Most of these tumors harbored an established oncogenic alteration.  We identified a novel <a href="https://www.ncbi.nlm.nih.gov/gene/100506658">OCLN</a>-<a href="https://www.ncbi.nlm.nih.gov/gene/5923">RASGRF1</a> fusion from one tumor that lacked a known oncogenic driver.  Functional studies demonstrated this fusion activates RAS signaling and promotes tumorigenesis in cell models.</p>

Genomic Features of Lung Adenocarcinoma from Individuals with    10    Pack-Year Smoking History

14 variables across Demographics, Disease Events, Race and Ethnicity + 1 more

Genomic Features of Lung Adenocarcinoma from Individuals with 10 Pack-Year Smoking History

Demographics (1)

Disease Events (4)

Race and Ethnicity (1)

Substance Use (1)

Other (7)