<p>Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the US. Driven by common disease common variants hypothesis, genome-wide association studies only identified a number of common susceptibility loci that explained a small portion of CRC heritability. We conducted a case-control study using whole exome sequencing to identify rare genetic variants with intermediate effect size that predispose individuals to colorectal cancer.</p>

The MD Anderson Colorectal Cancer Case Control Study

Colorectal Neoplasms study with SNP/CNV Genotypes (NGS), WXS data on dbGaP (5,384 participants)