<p>This study uses normal and tumor tissues from breast cancer patients to derive 3D cell culture models called organoids. Organoid technology is an innovative platform that can be used to study a patient's tumor in a dish <i>ex-vivo</i>. As part of this study we have comprehensively characterized these models using next-generation sequencing for: 1) pathogenic SNVs in a targeted gene panel 2) copy number alterations 3) transcriptome analysis using RNA sequencing and 4) single-cell RNA sequencing</p>

Patient-Derived Breast Cancer Organoid Study

1 selected publication including "Patient-derived triple negative breast cancer organoids provide robust..." (60 citations)

Patient-Derived Breast Cancer Organoid Study

Patient-derived triple negative breast cancer organoids provide robust model systems that recapitulate tumor intrinsic characteristics