The Sjögren's Genetics Network (SGENE) is an international collaboration focused on identifying and understanding the genetic variations that influence Sjögren’s pathology. Collectively, SGENE collaborators from 26 different sites (5 in the United States; 21 in foreign countries) have recruited a large cohort of geographically diverse participants of European ancestry. Recruitment, sample collection, and genotyping were performed at unique SGENE sites in compliance with local institutional review board approval. High-density SNP genotyping data were collated by the Oklahoma Medical Research Foundation (<a href="https://omrf.org/">OMRF</a>) and used to perform a GWAS of Sjögren's of European ancestry. 
Participants underwent extensive medical assessment for Sjögren's Syndrome using internationally accepted American-European Consensus Group (AECG) classification criteria or the American College of Rheumatology/European League Against Rheumatism classification criteria. 
Data quality control, GWAS imputation using the Haplotype Reference Consortium, panel version 1.1, and dbGaP preparation/posting were performed at the <a href="https://omrf.org/">OMRF</a>. To facilitate research focused on understanding the genetics of Sjögren's syndrome, the Genomic Summary Results from this GWAS are being made available herein using a total of n=3232 Sjögren's cases and n=17,481 controls. A total of n=8962 controls were obtained from our SGENE collaborators or from our previous study (Lessard, et al. Nature Genetics 2013. PMID: 24097067). To achieve adequate case-to-control ratios for the GWAS analyses, population-based control GWAS data were also obtained from dbGaP (<a href="https://www.ncbi.nlm.nih.gov/gap/advanced_search/?TERM=phs000428.v2.p2">phs000428.v2.p2</a>; <a href="https://www.ncbi.nlm.nih.gov/gap/advanced_search/?TERM=phs000672">phs000672.v1.p1</a>; <a href="https://www.ncbi.nlm.nih.gov/gap/advanced_search/?TERM=phs000196.v3.p1">phs000196.v3.p1</a>; <a href="https://www.ncbi.nlm.nih.gov/gap/advanced_search/?TERM=phs000187.v1.p1">phs000187.v1.p1</a>). 
In accordance with IRB approval, subject consents, and data sharing restrictions, we are also making available the individual-level genotyping data for a subset of Sjögren's cases (n=1,199) that were genotyped at the <a href="https://omrf.org/">OMRF</a>.

Discovery and Characterization of Genetic Risk Loci in Sjogren's Syndrome

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren’s syndrome