Cohort Description In 1948, the researchers recruited 5,209 men and women between the ages of 30 and 62 from the town of Framingham, Massachusetts, and began the first round of extensive physical examinations and lifestyle interviews that they would later analyze for common patterns related to CVD development. Since 1948, the subjects have returned to the study every two years for an examination consisting of a detailed medical history, physical examination, and laboratory tests, and in 1971, the study enrolled a second-generation cohort -- 5,124 of the original participants' adult children and their spouses -- to participate in similar examinations. The second examination of the Offspring cohort occurred eight years after the first examination, and subsequent examinations have occurred approximately every four years thereafter. In 1994, the need to establish a new study reflecting a more diverse community of Framingham was recognized, and the first Omni cohort of the Framingham Heart Study, consisting of 506 participants, was enrolled. In April 2002 4095 third generation of participants, the grandchildren of the original cohort, were added. In 2003, 103 spouses of the offspring Cohort (NOS), and a second group of 410 Omni participants were enrolled. Through 2019, the original cohort has completed a total of 32 exams, the Offspring cohort 9 exams, the OMNI1 cohort 4 exams, and GEN3, NOS and OMNI2 cohorts each have completed 3 exams. The FHS is a joint project of the National Heart, Lung and Blood Institute and Boston University. Data Being Submitted FIRST RELEASE <ul> <li>Wave 1 questionnaire data includes 3967 variables for up to 3112 FHS participants in C4R.</li> <li>Wave 2 questionnaire data includes 448 variables for up to 2337 FHS participants in C4R.</li> <li>Dried Blood Spot/Serosurvey data includes 7 variables for up to 2189 FHS participants in C4R.</li> <li>Derived data includes 43 variables for up to 3151 FHS participants in C4R.</li> <li>Phenotype data includes 113 variables for up to 3151 FHS participants in C4R.</li> </ul> SECOND RELEASE This new version includes C4R Freeze 2.0 data, which incorporates newly collected data from Wave 3; a review of medical records for COVID-19 events; Serosurvey 2.0; newly harmonized datasets for lung CT, brain MRI, and neurocognitive assessments; and updated datasets for derived and phenotype variables. Please note that Serosurvey 2.0, lung CT, brain MRI, and neurocognitive assessments are not available for all cohorts.

Collaborative Cohort of Cohorts for COVID-19 Research (C4R): Framingham Heart Study (FHS)

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