The California Teachers Study (CTS) is a prospective observational cohort of N=133,477 adult women who have been followed since 1995. Participants completed up to six surveys and have been linked with cancer, hospitalization, and mortality data. In 2013-2016, over 14,000 CTS participants donated blood samples for future research. For this project, DNA was extracted in 2023 from 1694 buffy coats and 56 blood clots from N=1750 CTS participants whose self-reported race/ethnicity was Asian (398), Asian or Pacific Islander (18), Black or African American (189), Native American (128), Native Hawaiian or Other Pacific Islander (66), White Hispanic (719), or more than one race (232). Whole genome sequencing (WGS) was performed at CIDR in 2023-2024. WGS data and accompanying phenotype data are available through dbGaP. In addition, all CTS data are available to the research community via the CTS Researcher Platform (<a href="www.calteachersstudy.org">www.calteachersstudy.org</a>), a secure cloud-based environment that includes data, software, documentation, and collaboration workspaces.

California Teachers Study (CTS): Whole Genome Sequences From Under-Represented Populations

High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States)

Insights from Adopting a Data Commons Approach for Large-scale Observational Cohort Studies: The California Teachers Study