<p>The study seeks to examine the genetic and ancestral basis of prostate cancer-associated inflammation
 using a genome-wide association approach. The study population are the participants of the NCI Maryland
 Prostate Cancer Case-Control study. This study recruited both African American and European
 American men, and investigated the causes for the excessive burden of prostate 
cancer among African American men in more general terms. We measured 82 blood-based immune-oncology markers, and
 genotyped the participants using the HumanOmni5-Quad BeadChip, which provides a significant genome 
coverage for genetically-admixed and diverse populations, to evaluate the genetic basis and evidence for 
causality of any immune-inflammation marker that is associated with prostate cancer risk. We want to
 assess how germline genetics influence the abundance levels of these 82 markers in African
American and European American men, which may contribute to differences between them.</p>

NCI-Maryland Prostate Cancer Case-Control Study

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