<p>To look for genetic correlates of disease progression, the GTAC study recruited patients with motor neuron disease from 13 academic medical center clinics and followed them longitudinally for up to 5 years. Participants were regularly assessed for changes in respiratory function, the ALS Functional Rating Scale, and the ALS Cognitive Behavioral Scale. Participants underwent PCR-free whole genome sequencing on the Illumina NovaSeq, as well as repeat-prime PCR assessment of the C9ORF72 repeat expansion. Participants had PBMCs and whole blood RNA banked for future correlative studies. </p>

Genomic Translation for ALS Care (GTAC) - WGS

15 variables across Demographics, Disease Events, Race and Ethnicity

Genomic Translation for ALS Care (GTAC) - WGS

Demographics (1)

Disease Events (1)

Race and Ethnicity (2)

Other (11)