<p>We performed Whole-Genome Sequencing (WGS) on 100 tumor and matched germline samples from 49 CD19-directed chimeric antigen receptor (CAR-19)-treated diffuse large B cell lymphoma (DLBCL) patients. We found that the presence of complex structural variants, APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide) mutational signatures, and genomic
damage from reactive oxygen species predict CAR-19 resistance. BAM files will be available through dbGaP.</p>

Whole-Genome Sequencing Reveals Complex Genomic Features Underlying    Anti-CD19 CAR T-Cell Treatment Failure in Lymphoma

1 selected publication including "Whole-genome sequencing reveals complex genomic features underlying an..." (61 citations)

Selected Publications — phs003023 — Whole-Genome Sequencing Reveals Complex Genomic Features Underlying    Anti-CD19 CAR T-Cell Treatment Failure in Lymphoma

Whole-Genome Sequencing Reveals Complex Genomic Features Underlying Anti-CD19 CAR T-Cell Treatment Failure in Lymphoma

Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphoma.