<p>To explore tumor heterogeneity in sporadic human basal cell carcinoma tumors, we profiled three individual patient tumors by scRNA-Seq and scATAC-Seq. Basal cell carcinomas (BCCs) are driven by hedgehog signaling with <a href="https://www.ncbi.nlm.nih.gov/gene/2735">GLI1</a> representing the key downstream transcription factor that drives tumor growth. <a href="https://www.ncbi.nlm.nih.gov/gene/2735">GLI1</a> as such is a readout of active hedgehog signaling. We identified that <a href="https://www.ncbi.nlm.nih.gov/gene/8581">LY6D</a> can mark squamous populations such as in squamous cell carcinomas (SCCs) that are negative for <a href="https://www.ncbi.nlm.nih.gov/gene/2735">GIL1</a> and hedgehog signaling. As such, both <a href="https://www.ncbi.nlm.nih.gov/gene/2735">GLI1</a> and <a href="https://www.ncbi.nlm.nih.gov/gene/8581">LY6D</a> can be used as biomarkers of BCCs and SCCs and their related states.</p>

Single Cell Analysis of Sporadic Human Basal Cell Carcinomas

14 variables across Demographics, Disease Events

Single Cell Analysis of Sporadic Human Basal Cell Carcinomas

Demographics (1)

Disease Events (1)

Other (12)