<p>Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine lung cancer often associated with oncogenic MYC amplifications, which are known to drive SCLC heterogeneity marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states. The genetic mechanisms of MYC amplification and phenotypic plasticity between cell states is not known. Using data from cell-lines and a few patient-derived samples along with integrated whole-genome sequencing, long-range optical mapping, single-cell DNA sequencing, and fluorescence in situ hybridization, we have attempted to successfully characterize extrachromosomal DNA (ecDNA) as the primary source of MYC amplifications and driver fusions in SCLC. </p>

Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer    Heterogeneity and is Associated with Worse Outcomes

Small Cell Lung Carcinoma study with OTHER, RNA-Seq + 2 more data on dbGaP (5 participants)

Selected Publications — phs003190 — Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer    Heterogeneity and is Associated with Worse Outcomes