<p>Small-cell lung cancer (SCLC) is a very aggressive neuroendocrine lung cancer often associated with oncogenic MYC amplifications, which are known to drive SCLC heterogeneity marked by neuroendocrine (NE) and non-neuroendocrine (non-NE) cell states. The genetic mechanisms of MYC amplification and phenotypic plasticity between cell states is not known. Using data from cell-lines and a few patient-derived samples along with integrated whole-genome sequencing, long-range optical mapping, single-cell DNA sequencing, and fluorescence in situ hybridization, we have attempted to successfully characterize extrachromosomal DNA (ecDNA) as the primary source of MYC amplifications and driver fusions in SCLC. </p>

Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer    Heterogeneity and is Associated with Worse Outcomes

15 variables across Demographics, Race and Ethnicity

Variables — phs003190 — Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer    Heterogeneity and is Associated with Worse Outcomes

Extrachromosomal DNA Amplification Contributes to Small Cell Lung Cancer Heterogeneity and is Associated with Worse Outcomes

Demographics (3)

Race and Ethnicity (1)

Other (11)