<a href="https://www.rhoworld.com/federal-project-pages/childrens-respiratory-and-environment-workgroup-crew/">Children's Respiratory Environment Workgroup</a> (CREW) is an NIH-funded project consisting of 12 individual U.S. cohorts and three scientific centers working together to identify phenotypes and causes of childhood asthma. CREW includes data from a large number of children and their families, with broad diversity in terms of ethnicity, family characteristics, neighborhoods and geographic locations. In this study, we identified differentially methylated regions from whole-genome bisulfite sequencing (WGBS) in nasal epithelial cells from 39 children of European or African ancestries, and with or without allergic asthma. Study participants were from two of the CREW cohorts: the Urban Environment and Childhood Asthma (URECA) cohort and the Childhood Origins of Asthma (COAST) cohort.The URECA children are also participants of a larger genetic study, in which DNA samples are derived from blood. That data is presented in the "<a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bihttps://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs002921">Whole Genome Sequencing in the Inner City Asthma Consortium (ICAC) Cohorts - phs002921</a>" study.

DNA Methylation Studies in CREW Cohorts (URECA and COAST)

A Functional Genomics Pipeline to Identify High-Value Asthma and Allergy CpGs in the Human Methylome.