<p>We performed targeted sequencing of the <a href="https://www.ncbi.nlm.nih.gov/gene/2312">FLG</a> gene in 438 children with physician-diagnosed Atopic Dermatitis (AD), identified Loss-of-Function (LoF) variants, and tested the association of having one or more of these variants (binary composite) variants with AD-associated outcomes. We found that having a LoF variant was associated with moderate-severe AD compared to mild AD, food allergy at the first visit, and higher transepidermal water loss (TEWL) in both lesional and non-lesional skin in these children.<br></p>

FLG LoF Variants are Associated with Atopic Dermatitis in an Early-Life Prospective Cohort

Events in Normal Skin Promote Early-life Atopic Dermatitis - the MPAACH Cohort.

Longitudinal atopic dermatitis endotypes: An atopic march paradigm that includes Black children.

Validation of a Parental Questionnaire to Identify Atopic Dermatitis in a Population-Based Sample of Children up to 2 Years of Age