<p>The National Cancer Institute (NCI) multi-ancestral genome-wide association study (GWAS) of kidney cancer ("NCI-3") was performed by NCI to further investigate common genetic variants associated with risk of kidney cancer and its two major subtypes across individuals of different ancestries (European, African, East Asian, Latin American). The NCI-3 GWAS includes 12,315 cases and 73,091 controls from 25 centers in North America, South America and Europe, genotyped using the Illumina Global Screening Array v2.0. SNP-level results from this GWAS were combined by meta-analysis with results from two earlier NCI European-ancestry GWAS (RCC; <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bihttps://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000351">phs000351</a>: 1,311 cases and 3,424 controls and <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bihttps://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs001736">phs001736</a>: 2,417 cases and 4,391 controls), a NCI GWAS of African Americans (<a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bihttps://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000863">phs000863</a>; 255 cases and 375 controls), GWAS conducted at other institutions [<a href="https://www.iarc.who.int/">International Agency for Research on Cancer</a> (scan 1: 2,438 cases and 5,071 controls; scan 2: 2,781 cases and 2,940 controls), <a href="https://www.mdanderson.org/">The University of Texas MD Anderson Cancer Center</a> (scan 1: 893 cases and 556 controls, scan 2: 1,241 cases and 1,712 controls) and the <a href="https://www.icr.ac.uk/">Institute for Cancer Research, UK</a> (944 cases and 4,024 controls)] and GWAS analyses of data from three large biobanks (<a href="https://biobankjp.org/en/">Biobank Japan</a>: 523 cases and 86,306 controls; <a href="https://www.finngen.fi/en">FinnGen</a>: 2,095 cases and 304,956 controls; <a href="https://www.ukbiobank.ac.uk">UK Biobank</a>: 1,807 cases and 348,824 controls). Only individual-level data from NCI-3 and the two MD Anderson Cancer Center scans are included in this dbGaP submission. All study-specific and meta-analysis summary statistics are included.</p>

National Cancer Institute Multi-Ancestry Genome-Wide Association Study of Kidney Cancer (NCI-3)