<p>Here, we colonized bronchial epithelial air-liquid interface tissue cultures with 58 different individual microbes. Following 18 and 48 hours of colonization, we performed bulk RNA-seq of the host epithelial cells (n=3). Overall, we found significant microbial species-level and strain-level variation in host gene expression changes for innate immunity and epithelial barrier genes. Of particular interest, we found significant heterogeneity in stimulation of host interferon and antiviral interferon-stimulated genes.</p><p>Study registered in <a href="https://www.immport.org/shared/home">ImmPort </a>under accession # SDY2281.</p>

Modulation of Lung Immune Responses to Viral Infection-Microbiome    Interactions with Respiratory Organoids

17 variables across Demographics, Race and Ethnicity

Modulation of Lung Immune Responses to Viral Infection-Microbiome Interactions with Respiratory Organoids

Demographics (3)

Race and Ethnicity (1)

Other (13)