<p>Desmoplastic Small Round Cell Tumor (DSRCT) is an aggressive mesenchymal tumor driven by fusions between the disordered domain of the Ewing sarcoma RNA binding protein 1 (<a href="https://www.ncbi.nlm.nih.gov/gene/2130">EWSR1</a>) and the developmental transcription factor Wilms tumor 1 (<a href="https://www.ncbi.nlm.nih.gov/gene/7490">WT1</a>). We used genome-wide chromatin profiling to identify EWSR1-WT1-dependent gene regulatory networks and target genes. Our studies show that EWS-WT1 is a powerful activator of distal regulatory elements and controls an oncogenic gene expression program that characterizes primary DSRCTs. ChIP-seq profiles for histone marks in primary DSRCT samples are available through dbGaP.</p>

EWS-WT1 Fusion Isoforms Establish Oncogenic Programs and Therapeutic    Vulnerabilities in Desmoplastic Small Round Cell Tumors

Variables — phs003682 — EWS-WT1 Fusion Isoforms Establish Oncogenic Programs and Therapeutic    Vulnerabilities in Desmoplastic Small Round Cell Tumors

EWS-WT1 Fusion Isoforms Establish Oncogenic Programs and Therapeutic Vulnerabilities in Desmoplastic Small Round Cell Tumors

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