<p>We recalled 23 sperm donors with prior banked samples to provide a new sperm sample. The old and new sequential sperm samples were then profiled by high-fidelity duplex sequencing to measure individual-specific mutation rates and patterns. We also performed deep whole-genome sequencing of sequential sperm samples from two individuals followed by targeted validation, which measured remarkably stable mosaicism of clonal mutations that likely arose during embryonic and germline development.<br></p>

Measurement of the Male Germline Mutation Rate Using Sequential Sperm    Samples

Mutation study with OTHER, Targeted-Capture + 1 more data on dbGaP (23 participants)