<p>This study focuses exclusively on the quantification of <a href="https://www.ncbi.nlm.nih.gov/gene/54596">LINE1</a> mobilization. We analyzed a recent whole genome sequencing data release from multiple <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178">Cancer Genome Atlas (TCGA)</a> sub-projects. In addition to the somatic LINE1 insertions (present in tumor and having no support in the matched normal) there are "pseudo-germline" non-reference LINE1 elements identified in tumor tissue and having some support in the matched normal. This dataset reports such "pseudo-germline" LINE1 retrotranspositions. Individual level data for TCGA can be accessed by requesting access to <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178">phs000178</a>.</p>

The Study of Somatic LINE1 Activity in Cancers

Neoplasms study with CNV (NGS) data on dbGaP (4,667 participants)

The Study of Somatic LINE1 Activity in Cancers

Description

Applying For Access

Summary