<p>This study focuses exclusively on the quantification of <a href="https://www.ncbi.nlm.nih.gov/gene/54596">LINE1</a> mobilization. We analyzed a recent whole genome sequencing data release from multiple <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178">Cancer Genome Atlas (TCGA)</a> sub-projects. In addition to the somatic LINE1 insertions (present in tumor and having no support in the matched normal) there are "pseudo-germline" non-reference LINE1 elements identified in tumor tissue and having some support in the matched normal. This dataset reports such "pseudo-germline" LINE1 retrotranspositions. Individual level data for TCGA can be accessed by requesting access to <a href="https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000178">phs000178</a>.</p>

The Study of Somatic LINE1 Activity in Cancers

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