Data Access NOTE: Please refer to the "Authorized Access" section below for information about how access to the data from this accession differs from many other dbGaP accessions.The PRIME-AIR study ("Positive end-expiratory pressure, Recruitment, Incentive spirometry, Muscle relaxant optimization, preoperative Education, postoperative early Ambulation, Individualized, and Reinforced") was a prospective multi-center randomized controlled pragmatic trial, with a blinded assessor, to compare post-operative pulmonary complications (PPCs) in patients with an individualized anesthetic-centered intervention (including individualized mechanical ventilation positive end-expiratory pressure (PEEP) management to maximize respiratory system compliance and minimize driving pressures, a neuromuscular agent and subsequent reversal, and post-operative lung expansion and early mobilization) versus usual care.

The PRIME-AIR Study: Positive End-Expiratory Pressure, Recruitment,    Incentive Spirometry, Muscle Relaxant Optimization, Preoperative    Education, Postoperative Early Ambulation, Individualized, and    Reinforced

2 selected publications including "Perioperative lung expansion and pulmonary outcomes after open abdomin..." (11 citations)

Selected Publications — phs003926 — The PRIME-AIR Study: Positive End-Expiratory Pressure, Recruitment,    Incentive Spirometry, Muscle Relaxant Optimization, Preoperative    Education, Postoperative Early Ambulation, Individualized, and    Reinforced

The PRIME-AIR Study: Positive End-Expiratory Pressure, Recruitment, Incentive Spirometry, Muscle Relaxant Optimization, Preoperative Education, Postoperative Early Ambulation, Individualized, and Reinforced

Perioperative lung expansion and pulmonary outcomes after open abdominal surgery versus usual care in the USA (PRIME-AIR): a multicentre, randomised, controlled, phase 3 trial.

An anesthesia-centered bundle to reduce postoperative pulmonary complications: The PRIME-AIR study protocol