<p>We investigated the immunological effects of B cell depletion therapy using ocrelizumab in treatment-naïve relapsing-remitting multiple sclerosis (RRMS) patients. Our primary aim was to delineate transcriptomic alterations in immune cell populations in peripheral blood before and after therapy, using single-cell RNA sequencing (scRNAseq). This study included 18 newly diagnosed, treatment-naïve RRMS patients who provided matched pre- and 6-month post-treatment peripheral blood mononuclear cells (PBMCs). A secondary cohort of five patients also contributed paired cerebrospinal fluid (CSF) samples. All RRMS patients were treated with ocrelizumab, except one patient in the CSF cohort who received rituximab.</p>

Transcriptomic Profiling after B-Cell Depletion Reveals Central and    Peripheral Immune Cell Changes in Multiple Sclerosis

Multiple Sclerosis study with RNA-Seq data on dbGaP (23 participants)

Selected Publications — phs003938 — Transcriptomic Profiling after B-Cell Depletion Reveals Central and    Peripheral Immune Cell Changes in Multiple Sclerosis