<p>Oral microbiota may influence head and neck squamous cell carcinoma (HNSCC) development, potentially related to carcinogen metabolism. The human oral cavity hosts a diverse microbiota, including bacteria and fungi. We performed shotgun sequencing and ITS1 sequencing on 236 HNSCC case participants who developed HNSCC during a mean follow-up of 5.1 years and 458 matched controls who remained HNSCC-free. Oral samples were obtained from a prospective nested case-control study within three epidemiological cohorts: the <a href="https://www.cancer.org/research/population-science/cancer-prevention-and-survivorship-research-team/acs-cancer-prevention-studies/cancer-prevention-study-2.html">American Cancer Society Cancer Prevention Study II Nutrition Cohort </a>(ACS CPS-II), the <a href="https://prevention.cancer.gov/major-programs/prostate-lung-colorectal-and-ovarian-cancer-screening-trial-plco">Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial </a>(PLCO), and the <a href="https://www.southerncommunitystudy.org/">Southern Community Cohort Study</a> (SCCS). Control participants were selected using 2:1 frequency matching based on cohort, age, sex, race and ethnicity, and time since oral sample collection.</p>

The Oral Microbiome and Head and Neck Cancer

Squamous Cell Carcinoma of Head and Neck study with AMPLICON, WGS data on dbGaP (694 participants)

The Oral Microbiome and Head and Neck Cancer

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