<p>Oral microbiota may influence head and neck squamous cell carcinoma (HNSCC) development, potentially related to carcinogen metabolism. The human oral cavity hosts a diverse microbiota, including bacteria and fungi. We performed shotgun sequencing and ITS1 sequencing on 236 HNSCC case participants who developed HNSCC during a mean follow-up of 5.1 years and 458 matched controls who remained HNSCC-free. Oral samples were obtained from a prospective nested case-control study within three epidemiological cohorts: the <a href="https://www.cancer.org/research/population-science/cancer-prevention-and-survivorship-research-team/acs-cancer-prevention-studies/cancer-prevention-study-2.html">American Cancer Society Cancer Prevention Study II Nutrition Cohort </a>(ACS CPS-II), the <a href="https://prevention.cancer.gov/major-programs/prostate-lung-colorectal-and-ovarian-cancer-screening-trial-plco">Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial </a>(PLCO), and the <a href="https://www.southerncommunitystudy.org/">Southern Community Cohort Study</a> (SCCS). Control participants were selected using 2:1 frequency matching based on cohort, age, sex, race and ethnicity, and time since oral sample collection.</p>

The Oral Microbiome and Head and Neck Cancer

1 selected publication including "Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Can..." (29 citations)

The Oral Microbiome and Head and Neck Cancer

Oral Microbiome and Subsequent Risk of Head and Neck Squamous Cell Cancer.