Single-Cell Atlas of Human Liver and Blood Immune Cells Across Fatty Liver Disease Stages
Anthropometry (1)
- BMI - Body Mass Index, a measure of body fat based on height and weight (phv00560420.v1.p1)
Biomarkers (9)
- ALBUMIN - A protein made by the liver; low levels may indicate liver dysfunction (phv00560430.v1.p1)
- ALP - Alkaline Phosphatase, an enzyme related to liver and bone health (phv00560433.v1.p1)
- ALT - Alanine Aminotransferase, an enzyme elevated in liver injury (phv00560426.v1.p1)
- AST - Aspartate Aminotransferase, an enzyme used to assess liver damage (phv00560427.v1.p1)
- GLOBULIN - Group of proteins in the blood; levels may be altered in liver disease (phv00560434.v1.p1)
- INR - International Normalized Ratio, measuring blood clotting ability (phv00560435.v1.p1)
- PLT - Platelet count in the blood, important for assessing liver function (phv00560429.v1.p1)
- TOTAL_BILI - Total bilirubin levels, indicating liver function and bile processing (phv00560431.v1.p1)
- TOTAL_PROTEIN - Total protein in the blood, reflecting liver function and nutritional status (phv00560432.v1.p1)
Demographics (3)
- AGE - Age of the subject when the sample was collected (phv00560419.v1.p1)
- SEX - Biological sex of the subject (male or female) (phv00560436.v1.p1)
- SEX - Biological sex (phv00560406.v1.p1)
Race and Ethnicity (2)
- ETHNICITY - The ethnic background of the subject (phv00560438.v1.p1)
- RACE - The racial background of the subject (phv00560437.v1.p1)
Other (24)
- ANALYTE_TYPE - The analyte type of the sample (ex. DNA, RNA) (phv00560441.v1.p1)
- APRI_SCORE - Index that estimates liver fibrosis using AST levels and platelet count (phv00560424.v1.p1)
- AST ULN - Upper Limit of Normal for AST, used to assess whether AST is elevated (phv00560428.v1.p1)
- BODY_SITE - The collection site of the sample (phv00560440.v1.p1)
- CAP - Controlled Attenuation Parameter, quantifying liver fat via ultrasound (phv00560421.v1.p1)
- CD163 - Soluble receptor from macrophages, often elevated in liver inflammation (phv00560425.v1.p1)
- CLINICAL_STAGE - Stage of progression for MASLD/MASH (Metabolic Dysfunction-associated Steatotic Liver Disease); F0-F4 refer to Brunt fibrosis stages (phv00560417.v1.p1)
- CONSENT - Registered consent groups (Data Use Limitations (DUL)) as determined by submitters' Institutional Review Boards (IRB) or equivalent body (phv00560405.v1.p1)
- FIB4_SCORE - Calculation estimating liver fibrosis based on age, AST, ALT, and platelets (phv00560423.v1.p1)
- FIBROSCAN - Non-invasive test measuring liver stiffness to assess fibrosis (phv00560422.v1.p1)
- FIBROSIS_STAGE - Stage of liver fibrosis, indicating the degree of liver scarring (phv00560418.v1.p1)
- GLYCOGENATED_NUCLEI - Presence of glycogen accumulation in liver cell nuclei, a histological feature (phv00560414.v1.p1)
- HEPATOCYTE_BALLOONING - Swelling of liver cells (hepatocytes), a sign of liver damage (phv00560412.v1.p1)
- IS_TUMOR - The tumor status of the sample (phv00560442.v1.p1)
- LOBULAR_INFLAMMATION - Inflammation in the liver's lobules, indicative of liver injury (phv00560411.v1.p1)
- NAFLD_ACTIVITY_SCORE - Composite score evaluating the severity of NAFLD based on histology (phv00560416.v1.p1)
- PORTAL_INFLAMMATION - Inflammation in the liver's portal areas, a marker of chronic liver disease (phv00560413.v1.p1)
- SAMPLE_ID - Sample ID (phv00560439.v1.p1)
- SAMPLE_ID - Sample ID (phv00560408.v1.p1)
- STEATOHEPATITIS - Liver inflammation associated with fat accumulation, often leading to nonalcoholic steatohepatitis (NASH) (phv00560415.v1.p1)
- STEATOSIS_GRADE - Grading of liver fat accumulation (steatosis) severity (phv00560410.v1.p1)
- SUBJECT_ID - Unique identifier for the subject (phv00560409.v1.p1)
- SUBJECT_ID - Subject ID (phv00560404.v1.p1)
- SUBJECT_ID - Subject ID (phv00560407.v1.p1)