<p>We aimed to define the target genes and pathways in which autoimmune disease-associated genetic variants operate. We performed single cell-CRISPR-interference screens in primary human T cells and bulk RNA-seq on T cells containing CRISPRi and single gRNAs to assess how T cell regulatory regions containing autoimmune-associated genetic variants affect nearby gene expression and cellular programs. </p>

Genetic and Epigenetic Screens in Primary Human T Cells Link Candidate    Causal Autoimmune Variants to T Cell Networks

16 variables across Demographics, Race and Ethnicity

Genetic and Epigenetic Screens in Primary Human T Cells Link Candidate Causal Autoimmune Variants to T Cell Networks

Demographics (2)

Race and Ethnicity (1)

Other (13)