<p>This is a single-cell RNA sequencing (scRNA-seq) study using peripheral blood mononuclear cells (PBMC) from 3 healthy donors and 2 patients with OTULIN-related Pyoderma Gangrenosum (ORP). Samples were not hashed or multiplexed. The 10X Genomics Platform was used for sequencing. Principal findings include transcriptome changes due to a mutation in <a href="https://www.ncbi.nlm.nih.gov/gene/90268">OTULIN</a> that causes OTULIN-Related Pyoderma gangrenosum (ORP), without affecting OTULIN function but abrogating its binding ability to the linear ubiquitin assembly complex (LUBAC). FASTA files will be available through dbGaP. </p>

Pyoderma Gangrenosum Caused by Molecular Uncoupling of OTULIN Catalytic    Activity and LUBAC Binding

11 variables across Demographics, Disease Events

Pyoderma Gangrenosum Caused by Molecular Uncoupling of OTULIN Catalytic Activity and LUBAC Binding

Demographics (1)

Disease Events (1)

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