African Americans have one of the highest rates of type 2 diabetes in the United States, and often have other medical problems related to obesity and cardiovascular disease. These conditions have various risk factors, including high blood sugar levels, high cholesterol levels, and insulin resistance. However, these risk factors need further study in individuals with African ancestry, including Afro-Caribbean and sub-Saharan Africa migrant populations. Genetic study of obesity, adult-onset diabetes, heart disease, and other common health conditions in African ancestry individuals across the Diaspora could be particularly informative. Therefore, this study is designed to collect genetic and non-genetic information from individuals with African ancestry to study common health conditions related to obesity, adult-onset diabetes, and heart disease. This ongoing study includes individuals at least 18 years of age who self-identify as African American, Afro-Caribbean, or migrants from sub Saharan Africa. Participants undergo physical examination and provide a blood sample for study. Participants also answer questions about personal and family medical history and current lifestyle behaviors. No treatment is provided as part of this protocol.

The Genetics of Obesity, Diabetes, and Heart Disease in African Diaspora    Populations

Obesity study with SNP Genotypes (NGS) data on dbGaP (534 participants)